Quinoa and Chia Modulate AMPK/PPAR-ɣ Signaling in High-Fat Diet–Induced Obesity Rat Model

Abstract Obesity is one of the principal reasons behind a wide range metabolic diseases and dramatic health complications. Recent studies shed light on chia ( Salvia hispanica L., Lamiaceae) quinoa Chenopodium Willd., Amaranthaceae) seeds identified them as products utmost benefits. The present study was designed to explore molecular mechanisms hydroalcoholic extract those in weight management. Rats were divided randomly into two main groups: control treated. groups received regular chow diet, high-fat green tea. treated diet or extracts. Results revealed that showed hepatoprotective effects anti-inflammatory antioxidant activities, modulated leptin, adiponectin, serum lipid, glycemic profiles. Effects are further consolidated by normal hepatic tissue architecture upon histopathological examination. Moreover, modulation peroxisome proliferator-activated receptors-γ transcriptional activity via activation 5′AMP-activated protein kinase suppression nuclear expression sterol regulatory element-binding protein-1c obese rats compared tea demonstrated. Characterization major secondary bioactive metabolites done using HPLC/PDA/ESI-MS/MS. Our advocates evidence-based nutrition claims use extracts nutraceutical supplements for promoting wellness alleviating its related disorders.